Ibrutinib: A narrative drug review
Ibrutinib is an oral, irreversible covalent inhibitor of the Bruton tyrosine kinase, that plays a major role in B-cell differentiation, proliferation, migration, survival, Ironing Board and apoptosis.It has been found to be active against a number of B-cell malignancies.Ibrutinib has shifted the treatment strategy for malignancies away from cytotox